报 告 人

王迪  浙江大学医学院教授

报告时间

2023年11月3日（星期五）下午3：10—4：10

报告地点

医学院437会议室

报

告

内

容

简

介

报告内容简介：

Goblet cells and their main secretory product, mucus, play crucial roles in orchestrating the colonic host-microbe interactions that help maintain gut homeostasis. However, the precise intracellular machinery underlying this goblet cell-induced mucus secretion remains poorly understood. Gasdermin D (GSDMD) is a recently identified pore-forming effector protein that causes pyroptosis, a lytic proinflammatory type of cell death occurring during various pathophysiological conditions. Here, we reveal an unexpected function of GSDMD in goblet cell mucin secretion and mucus layer formation. Specific deletion of Gsdmd in intestinal epithelial cells (ΔIEC) led to abrogated mucus secretion with a concomitant loss of the mucus layer. This impaired colonic mucus layer in GsdmdΔIEC mice featured a disturbed host-microbial interface and inefficient clearance of enteric pathogens from the mucosal surface. This study links epithelial GSDMD to the secretory granule exocytotic pathway and highlights its physiological nonpyroptotic role in shaping mucosal homeostasis in the gut.

报告人简介：

王迪，浙江大学求是特聘教授，浙江大学医学院副院长（分管研究生工作），感染与免疫研究中心主任。作为最后通讯作者在Immunity (2016, 2018)，Science Immunology，Cell Metabolism，Molecular Cell (2019, 2020)，Developmental Cell，Nature Communications等国际权威学术杂志上发表多篇学术论文。获得国家杰出青年基金、优秀青年基金资助，入选教育部“青年长江学者”、浙江省“万人计划”科技创新领军人才、浙江省有突出贡献青年科技人才，荣获浙江省优秀博士论文导师 (2018, 2021)，药明康德生命化学研究学者奖，树兰医学青年奖等。

承办学院

医学院

发布日期

2023-10-30

欢迎广大教师、学生参加！